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The primary objective of the study was to evaluate the efficacy of nevirapine versus ZDV+3TC (Zidovudine + Lamivudine), when administered in labor and again at postdelivery, in reducing peripartum mother to child transmission of HIV (Human Immunodeficiency Virus). The secondary objective was to assess the overall HIV transmission rate between the 2 groups (intrauterine, intrapartum and postpartum up to 6 weeks) as well as to explore the relationship between infection and timing of maternal dose relative to birth, infant feeding method, maternal peripheral blood viral load, and other potential risk factors for transmission. Following the introduction of the second and third Amendments to the Protocol, 2 substudies were added. The objectives of these substudies were to evaluate the frequency of resistance-conferring mutations to nevirapine (Amendment 2) and to ZDV+3TC (Amendment 3); to determine whether there was a reversion of any resistant virus to the wild type; and to determine if the resistant virus was transmitted from the mother to the child. Condition or disease Intervention/treatment Phase HIV Infections Drug: Nevirapine Drug: Zidovudine (ZDV) Drug: Lamivudine (3TC) Phase 3. Layout table for study information Study Type: Interventional (Clinical Trial) Actual Enrollment: 2648 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Prospective Randomised Open Label Clinical Trial to Determine the Efficacy of Nevirapine, Compared With a Combination of ZDV + 3TC, in Decreasing the Peripartum Mother to Child Transmission of HIV. Women, Who Present After 38 Weeks Gestation or in Labour After 35 Weeks Gestation and Who Are Anti-retroviral Naive, Will be Included.

Study Start Date: April 1999 Actual Primary Completion Date: January 2001. Inclusion Criteria: • Pregnant women who present after 38 weeks gestation or in labour after 35 weeks gestation who are tested HIV positive. Estimated gestational age will be determined by one or more of the following: • Reliable menstrual history, which corresponds with uterine size • Physical examination • Estimated fetal weight • A consent form for the mother and neonate will be signed by either the mother or the guardian prior to inclusion Exclusion Criteria: • Mothers who have taken any antiretrovirals in the last 12 months • Mothers who are not able to take oral medication • Mothers who present with ARDS (acute respiratory distress syndrome), septic shock or eclampsia • Mothers presenting in discomfort, i.e. Layout table for MeSH terms HIV Infections Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Lamivudine Zidovudine Nevirapine Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anti-Retroviral Agents Antiviral Agents Anti-Infective Agents Anti-HIV Agents Antimetabolites Cytochrome P-450 CYP3A Inducers Cytochrome P-450 Enzyme Inducers.

I believe it may be the Tritons, but there are probably other part-fish, part-humans. Plus, there was a fish-headed god in antiquity (not greco-roman). A side note is that there were some mistranslations and some of the 'sirens' in Greek tales were half-birds and not half-fish (i.e., harpies and not mermaids). 'In Greek mythology, the Sirens were three dangerous bird-women, portrayed as seductresses who lured nearby sailors with their enchanting music and voices to shipwreck on the rocky coast of their island. Roman poets placed them on an island called Sirenum scopuli. In some later, rationalized traditions, the literal geography of the 'flowery' island of Anthemoessa, or Anthemusa, is fixed: sometimes on Cape Pelorum and at others in the islands known as the Sirenuse, near Paestum, or in Capreae.

All such locations were surrounded by cliffs and rocks. When the Sirens were given a parentage they were considered the daughters of the river god Achelous, fathered upon Terpsichore, Melpomene, Sterope, or Chthon (the Earth; in Euripides' Helen 167, Helen in her anguish calls upon 'Winged maidens, daughters of the Earth').

Although they lured mariners, for the Greeks the Sirens in their 'meadow starred with flowers' were not sea deities. Roman writers linked the Sirens more closely to the sea, as daughters of Phorcys.

Their number is variously reported as between two and five. In the Odyssey, Homer says nothing of their origin or names, but gives the number of the Sirens as two. Later writers mention both their names and number: some state that there were three, Peisinoe, Aglaope, and Thelxiepeia. The Sirens of Greek mythology are sometimes portrayed in later folklore as fully aquatic and mermaid-like; the facts that in Spanish, French, Italian, Polish, Romanian and Portuguese the word for mermaid is respectively Sirena, Sirene, Sirena, Syrena, Sirena and Sereia, and that in biology the Sirenia comprise an order of fully aquatic mammals that includes the dugong and manatee, add to the visual confusion, so that Sirens are even represented as mermaids. However, 'the sirens, though they sing to mariners, are not sea-maidens,' Harrison had cautioned; 'they dwell on an island in a flowery meadow.' - EDIT from comments Plus, there was a fish-headed god in antiquity (not greco-roman) could you name him/her?